AIM-HIV PROJECT------------------------Instituto Salud Carlos III

Prevention strategies

Several strategies have been proposed to decrease the rate of sexual transmission of HIV: sex education, increase the availability and use of male and female condoms, circumcision, early treatment of infected people (test and treat strategy) and microbicides. Besides, pre-exposure treatment is an alternative strategy under study at present. The efficacy of different strategies is summarised in the next figure and the advantages and disadvantages of the methods are briefly discussed. With regard to microbicides, extensive information can be found in the following sections.

Correct and consistent use of condoms is one proven method of preventing HIV transmission; however, condoms are widely regarded as inadequate prevention options for women, who are often unable to negotiate condom use with their partners. Additionally, condoms are not an option for women who wish to become pregnant, and women who are having sex with men in exchange for gifts or money may be reluctant to use condoms if the men are willing to pay more for sex without a condom. The female condom has been marketed as an alternative barrier method, but this device is relatively costly and requires a certain level of skill, as well as acceptance by the male partner.

Studies have shown that male circumcision is an effective means of reducing HIV infection in heterosexual men; however, it does not appear to be effective in reducing transmission rates to women.

Treatment of the infected partner-Test and treat strategy.
There is also recent evidence that maintaining viral loads below detectable limits through the use of antiretroviral therapy significantly reduces the likelihood of transmission, but antiretroviral therapy is still not widely available in many regions.

Pre-exposure treatment
Treatment with antiretrovirals before sexual intercourse has been proposed as a method to avoid HIV transmission. Results show a partial protection of the exposed partner that can decrease the rate of transmission up to 50%. However, treatment should be started 24 hours before the sexual encounter and maintained 24 hours after. This is barely feasible in the context of countries with low access to treatment.  

NEWS 01  


Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of menstrual cycle. Read more.    




10/01/2014. The partners of the project and the Scientific Advisory Board attended the Progress Meeting of the project in Madrid.  



October 7-10, 2013. ISCIII and SEPROX presented an oral communication and a poster in the AIDS Vaccine Conference. Read more.


Instituto de Salud Carlos III. 2013. All rights reserved

This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 305938.

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