AIM-HIV PROJECT------------------------Instituto Salud Carlos III

What is a microbicide?

A microbicide is a drug used prior to sexual intercourse to kill or inactivate an infectious microorganism in order to prevent its transmission. Microbicides are characterized by its route of application. Typically they are applied directly as a cream or gel to the vagina or rectum hindering microorganism entry and transmission. Microbicides are especially important in the prevention of sexually transmitted infections (STIs), such as HIV. In the particular case of HIV-1 an intensive research aiming at microbicides development has been undertaken and, despite the fact that no full protection has been achieved, recent promising results of a tenofovir-based gel have raised hopes that an additional effective female-initiated prevention option may soon become viable (CAPRISA 004 trial).

However, in spite of this promising behaviour, the effectiveness shown by tenofovir gel in the CAPRISA trial was below 50% raising the need for more effective microbicides able to provide long-term full protection from sexual transmission of HIV in women and also for men that have sex with men (MSM).

NEWS 01  


Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of menstrual cycle. Read more.    




10/01/2014. The partners of the project and the Scientific Advisory Board attended the Progress Meeting of the project in Madrid.  



October 7-10, 2013. ISCIII and SEPROX presented an oral communication and a poster in the AIDS Vaccine Conference. Read more.


Instituto de Salud Carlos III. 2013. All rights reserved

This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 305938.

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